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Effects of selegiline, phenylpropanolamine, or a combination of both on physiologic and behavioral variables in healthy dogs
Leah A. Cohn, John R. Dodam, Balazs Szladovits
Revue : American Journal of Veterinary Research
Objective
To determine effects of selegiline hydrochloride, phenylpropanolamine (PPA), or a combination of both on physiologic and behavioral variables in dogs.
Animals
40 adult hound-type dogs.
Procedure
Dogs were assigned to 4 groups. One group received selegiline (1 mg/kg, PO, q 24 h) and PPA (1.1 mg/kg, PO, q 8 h), a second group received selegiline alone, a third group received PPA alone, and a fourth group received neither drug. Dogs were observed 3 times/d throughout the 30-day study (daily during the first week, on alternate days during the next 2 weeks, and again daily during the final week). Observers recorded rectal temperature, pulse, respiratory rate, oscillometric blood pressure, and lead-II ECG and assessed 4 behaviors, using an analogue scale. Variables were compared among treatment groups by use of a 2-factor ANOVA with data categorized into three 10-day treatment periods. A similar comparison was made among treatment groups with data categorized by time of observation (morning, afternoon, or evening) for all study days.
Results
Variables did not differ among groups at study initiation. Pulse rate was the only variable that differed significantly among treatment groups during the study. During the first 10 days of treatment, dogs receiving PPA had a lower pulse rate than dogs that did not. Although signs of illness were apparent in a few dogs, illness did not appear to be related to treatment.
Conclusion and Clinical Relevance
Adverse effects were not detected after administration of selegiline, PPA, or a combination of the drugs in healthy dogs
American Journal of Veterinary Research June 2002, Vol. 63, No. 6, Pages 827-832
Lien
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